Dr. Mercola: Molybdenum: In The Race For Beating Cancer

Molybdenum has been reported as an essential element in soil for the prevention of the production of agents that cause cancer such as nitrosamines in plant foods. It is an element that helps metabolize fats and carbohydrates as well as amino acids in the body. Its importance to overall health has been well documented.

Molybdenum has been known to be an important catalyst for enzymes. Apart from its enzymatic activity in acting as a cofactor for enzymes, it lowers the copper levels in the body in the form of Tetrathiomolybdate and hence is helpful in treating the autoimmune and the inflammatory diseases.

It has been shown in animal studies that, "Molybdenum dramatically inhibits pulmonary and liver fibrosis, which is thickening and scarring of tissue, helps prevent liver damage from acetaminophen and reduces heart damage from doxorubicin, a bacterial antibiotic. Tetrathiomolybdate also shows a partially protective effect against diabetes."

It helps in decreasing tooth decay and is a cofactor for a number of enzymes such as Sulfite oxidase, Xanthine oxidase, Aldehyde oxidase and xanthine oxidase as well as Mitochondrial amidoxime reducing component (mARC).

 According to the Linus Pauling Institute, "Copper is also a required cofactor for enzymes involved in inflammation and angiogenesis, known to accelerate cancer progression and metastasis. Copper depletion studies employing thiomolybdate have been initiated in patients with advanced malignancies with the aim of preventing disease progression or relapse. These pilot trials showed promising results in individuals with metastatic kidney cancer, metastatic colorectal cancer and breast cancer with high risk of relapse."

It has been reportedly found that in a small region of Northern China, cancer of the esophagus as well as stomach is around ten times higher than China's average prevalence and around 100 times higher than in the U.S. According to one study, "The soil in this region is low in molybdenum and other mineral elements; therefore, dietary molybdenum intake is also low. Studies conducted in other areas of low and high incidence of esophageal cancer showed that content of molybdenum and zinc in hair and nails is significantly lower in inhabitants of high-risk regions compared to cold spots. Moreover, esophageal cancer patients display reduced content of the trace elements compared to healthy relatives."

Molybdenum’s popularity as an anticancer agent is due to its ability to stop the production of nitrosamines. Acc to Live-strong, "When there's a deficiency of molybdenum uptake in plants, nitrosamines are produced because nitrate reductase — an enzyme — can't perform properly without its molybdenum co-factor."

Molybdenum has antioxidant properties that may help in fighting reduced immunity. The average recommended daily allowance for this mineral is 45 micrograms for adults and is mostly found in plant based food as the mineral exists in soil mostly although nowadays supplements are also available.

References:

Mercola.com

Livestrong June 11, 2015

Journal of Inorganic Biochemistry May 2006, Volume 100, Issues 5-6, Pages 927-930


J Biol Chem. 2010 Nov. 26.;285(48):37847-59

Adv Nutr. 2012 September 1;3(5):666-74

Linus Pauling Institute 2001-2016

Arch Iran Med. 2008 July;11(4):392-6

 

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